Signaling bias of the protease-activated receptor-1 is dictated by distinct GRK5 and β-arrestin-2 determinants
Monica L. Gonzalez Ramirez, Lennis B. Orduña-Castillo, Carolyne Bardeleben, Huaping Qin, Ying Lin, Cierra A. Birch, Irina Kufareva, JoAnn Trejo
This study identifies the molecular mechanisms underlying signaling bias in PAR1, showing distinct roles of GRK5 and β-arrestin-2 in thrombin- and APC-induced responses.
Cell Reports · Mar 1, 2026Peer-reviewedCell Biology