Neural Arming Niche in Tumor-Draining Lymph Nodes Programs CD8⁺T Cell Cytotoxicity via GZMB Norepinephrinylation
Yang Yan, Xueli Zhang, Aziguli Tulamaiti, Shu-Yu Xiao, Yun-Zhen Qian, Jiamei Luo, Guang-Hong Su, Rui Lu, Junjie Wang, Hong-Tai Ma, Xiaqing Li, Wen-Tao Shi, Yuan-Xin Hong, Hou Jing-li, Li-Peng Hu, , Zhi-Gang Zhang
The paper shows that sympathetic norepinephrine in tumor-draining lymph nodes modifies GZMB in CD8 T cells to enhance cytotoxicity and improve tumor control.
bioRxiv · Feb 26, 2026 · PreprintCancer Biology