Globally prevalent Kelch13 mutations increase partial artemisinin resistance and fitness in Bangladeshi Plasmodium falciparum parasites
Maisha Khair Nima, Nirjhar Bhattacharyya, Jungyoon Park, Douglas A. Shoue, Ching Swe Phru, Saiful Arefeen Sazed, Sudhir Kumar, Mohammad Shafiul Alam, Michael T. Ferdig, Angana Mukherjee
The paper evaluates the impact of K13 mutations on artemisinin resistance and parasite fitness in Bangladeshi Plasmodium falciparum isolates, finding that R561H confers extreme resistance and fitness advantages.
bioRxiv · Apr 25, 2025 · PreprintMicrobiology