FBP1 is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness
Li Gu, Yahui Zhu, Kosuke Watari, Maiya Lee, Junlai Liu, Sofia Perez, Melinda Thai, Joshua E. Mayfield, Bichen Zhang, Karina Cunha e Rocha, Fuming Li, Laura C. Kim, Alexander Curtis Jones, Igor H. Wierzbicki, Xiao Liu, , Michael Karin
The paper identifies FBP1 as a nonenzymatic regulator that inhibits AKT activation to prevent insulin hyperresponsiveness and associated liver pathologies.
bioRxiv · Mar 5, 2023 · PreprintMolecular Biology