Igor H. Wierzbicki

Mapping bacterial bile amidation across the bile salt hydrolase family

The paper maps bacterial bile amidation by analyzing BSH transaminase activities and identifying BBAs in human samples.

Rapid optogenetic blockade of autophagy reveals that nuclear pore complex proteins are robust autophagy substrates

The paper develops an optogenetic tool to rapidly inhibit autophagy and identifies nuclear pore complex proteins as autophagy substrates.

Ligand-induced Conformational Plasticity of the CTLH E3 Ligase Receptor GID4

This study designs high-affinity ligands for the E3 ligase GID4 to enable targeted protein degradation, identifying conformational changes and potential degrader structures, though degradation efficacy remains to be optimized.

A Robust Crystallographic Platform for High-Throughput β-Catenin Ligand Discovery

This paper develops a robust crystallographic platform for discovering β-catenin ligands through optimized protein production and screening methods.

Giant polyketide synthase enzymes biosynthesize a giant marine polyether biotoxin.

The paper identifies giant polyketide synthase genes in Prymnesium parvum that biosynthesize large polyether toxins, resolving a long-standing biosynthetic mystery.

FBP1 is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness

The paper identifies FBP1 as a nonenzymatic regulator that inhibits AKT activation to prevent insulin hyperresponsiveness and associated liver pathologies.