Alexandra C. Newton

A Catalytically Inactive Protein Kinase C alpha Mutation Drives Chordoid Glioma by Pathway Rewiring

This study identifies a catalytically inactive PKCα mutation that drives chordoid glioma by rewiring cellular interactions and impairing cell junction function.

Sex specific disruptions in Protein Kinase Cγ signaling in a mouse model of Spinocerebellar Ataxia Type 14

The paper develops a mouse model of SCA14 with a clinically relevant PKCγ mutation, identifies sex-specific disease mechanisms, and highlights potential therapeutic targets for males.

Sensitive Fluorescent Biosensor Reveals Differential Subcellular Regulation of PKC

The paper introduces a sensitive fluorescent biosensor, ExRai-CKAR2, to study subcellular PKC activity and finds differential regulation of PKC isoforms at the ER, lysosomes, and Par complexes.

Different signaling interpretations by PKC eta and theta control T cell function and exhaustion

This study shows PKC theta sustains T cell function while PKC eta drives terminal exhaustion, with distinct downstream cascades and therapeutic implications for cancer immunotherapy.

Proteome-wide base editor screens to assess phosphorylation site functionality in high-throughput

The paper uses base editor screens to assess phosphorylation site functionality in T cell activation, identifying novel sites that modulate transcriptional activity and signaling pathways.

Single-residue mutation in protein kinase C toggles between cancer and neurodegeneration

The paper shows how a single amino acid change in PKCβ's C1A domain can switch between cancer-promoting and neurodegenerative effects by altering autoinhibition and degradation.

FBP1 is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness

The paper identifies FBP1 as a nonenzymatic regulator that inhibits AKT activation to prevent insulin hyperresponsiveness and associated liver pathologies.