Michael Karin

Fatty acid scavenging enables cancer escape from KRAS inhibition

The paper identifies a metabolic adaptation in KRAS-inhibited cancer cells that enables resistance through fatty acid scavenging via ADGRB1-PI3Kγ signaling, and shows targeting this pathway restores sensitivity to KRAS inhibitors.

Inflammatory memory disables a DDR1 degradation checkpoint to enable pancreatic cancer growth

The paper identifies an inflammatory memory mechanism that disables DDR1 degradation, promoting pancreatic cancer growth by preserving DDR1 stability.

Disruptors of sestrin-MAPK interactions rejuvenate T cells and expand TCR specificity

This paper develops DOS, a first-in-class disruptor of sestrin-MAPK complexes, which rejuvenates senescent T cells and expands TCR specificity by generating new T cell clones.

FBP1 is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness

The paper identifies FBP1 as a nonenzymatic regulator that inhibits AKT activation to prevent insulin hyperresponsiveness and associated liver pathologies.