Interaction of G2019S LRRK2 and metabolic syndrome in a two-hit mouse model of Parkinson's disease: LRRK2-driven systemic depletion of pyrimidine nucleosides
Yue Ma, Madalynn L. Erb, Kayla A. Sipple, Alina V. Offerman, Junwei Niu, Zachary Madaj, Zhen Fu, Kin H. Lau, Darren J. Moore
The paper investigates how G2019S LRRK2 interacts with metabolic syndrome in a mouse model of Parkinson's disease, showing systemic nucleotide and energy metabolism disruptions and mitochondrial dysfunction.
npj Parkinson s Disease · Jul 8, 2026Peer-reviewedNeuroscience