Author

Kayla A. Sipple

Van Andel Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Assay:metabolomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Darren J. MooreiD· 3 shared Madalynn L. ErbiD· 2 shared Alexis L. Bergsma· 1 shared Alina V. OffermaniD· 1 shared Caio M. MassariiD· 1 shared Dylan J. Dues· 1 shared Erin T. WilliamsiD· 1 shared Junwei Niu· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersNeuroscience

Darren J. MooreORCID

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Author profile →

3 papers

Recent·Most cited

Interaction of G2019S LRRK2 and metabolic syndrome in a two-hit mouse model of Parkinson's disease: LRRK2-driven systemic depletion of pyrimidine nucleosides

Yue Ma, Madalynn L. Erb, Kayla A. Sipple, Alina V. Offerman, Junwei Niu, Zachary Madaj, Zhen Fu, Kin H. Lau, Darren J. Moore

The paper investigates how G2019S LRRK2 interacts with metabolic syndrome in a mouse model of Parkinson's disease, showing systemic nucleotide and energy metabolism disruptions and mitochondrial dysfunction.

npj Parkinson s Disease · Jul 8, 2026Peer-reviewedNeuroscience

Neuropathology in an α-synuclein preformed fibril mouse model occurs independent of the Parkinson's disease-linked lysosomal ATP13A2 protein

Caio M. Massari, Dylan J. Dues, Alexis L. Bergsma, Kayla A. Sipple, Maxwell A. Frye, Erin T. Williams, Darren J. Moore

This study shows that α-synuclein pathology spreads independently of ATP13A2 in a mouse model, indicating ATP13A2 is not critical for -syn clearance or propagation.

Neurobiology of Disease · Oct 13, 2024Peer-reviewedNeuroscience

Adult-Onset Deletion of ATP13A2 in Mice Induces Progressive Nigrostriatal Pathway Dopaminergic Degeneration and Lysosomal Abnormalities

Madalynn L. Erb, Kayla A. Sipple, Nathan D. Levine, Xi Chen, Darren J. Moore

This study shows that deleting ATP13A2 in adult mice leads to progressive dopaminergic degeneration and lysosomal issues, mimicking human neurodegenerative diseases.

npj Parkinson s Disease · Jul 19, 2024Peer-reviewedNeuroscience