Zhen Fu

Blocking MAT2A-driven SAM synthesis in ovarian cancer cells prevents cisplatin-induced DNA hypermethylation, impairs DNA repair signaling, and blocks stem cell enrichment, sensitizing MTAP-proficient and MTAP-deficient lines.

This study identifies kainate receptors' role in coordinating primitive hematopoiesis and hemogenic niche organization in zebrafish, showing their impact on hematopoietic stem cell development through endothelial Notch signaling.

The paper identifies novel regulators of quiescence-to-proliferation transitions in Drosophila follicle stem cells by analyzing gene expression changes during feeding.

The paper investigates how G2019S LRRK2 interacts with metabolic syndrome in a mouse model of Parkinson's disease, showing systemic nucleotide and energy metabolism disruptions and mitochondrial dysfunction.

This study shows that Tet1 dosage in midbrain neurons determines binge-eating susceptibility in mice and links Tet1 methylation to human binge-eating behavior.

This study examines methylome changes and immune cell shifts in SCLC patients treated with guadecitabine, revealing hypomethylation and altered immune profiles.

This study uses spatial transcriptomics to identify increased epithelium-macrophage signaling in endometriotic lesions, highlighting a new role for Complement 3 in lesion inflammation.

This study shows that H2B variants alter chromatin structure and oncogenic gene expression, suggesting they may be early cancer biomarkers and therapeutic targets.