Author

Madalynn L. Erb

Van Andel InstituteORCID 0000-0002-7651-6826Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 4 Approach:experimental assay· 3 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Organism:human· 1 Assay:metabolomics· 1 Assay:proteomics· 1

Frequent Co-Authors

Darren J. MooreiD· 4 shared Kayla A. Sipple· 2 shared Alina V. OffermaniD· 1 shared Allison ChangiD· 1 shared Alysa KaseniD· 1 shared An Phu Tran Nguyen· 1 shared Andrew B. WestiD· 1 shared David G. StandaertiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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4 shared papersNeuroscience

Darren J. MooreORCID

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4 papers

Recent·Most cited

Neurosciencenpj Parkinson s DiseasePeer-reviewedJul 8, 2026

Interaction of G2019S LRRK2 and metabolic syndrome in a two-hit mouse model of Parkinson's disease: LRRK2-driven systemic depletion of pyrimidine nucleosides

Yue Ma, Madalynn L. Erb, Kayla A. Sipple…·Darren J. Moore

The paper investigates how G2019S LRRK2 interacts with metabolic syndrome in a mouse model of Parkinson's disease, showing systemic nucleotide and energy metabolism disruptions and mitochondrial dysfunction.

1 citation

mousebulk RNA-seq

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NeuroscienceTranslational NeurodegenerationPeer-reviewedJun 19, 2025

Pathological α-synuclein elicits granulovacuolar degeneration independent of tau

Dylan J. Dues, Madalynn L. Erb, Alysa Kasen…·Darren J. Moore

This study shows that pathological α-synuclein can cause granulovacuolar degeneration independently of tau, using a mouse model of α-synucleinopathy.

3 citations

mouseexperimental assay

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Neurosciencenpj Parkinson s DiseasePeer-reviewedJul 19, 2024

Adult-Onset Deletion of ATP13A2 in Mice Induces Progressive Nigrostriatal Pathway Dopaminergic Degeneration and Lysosomal Abnormalities

Madalynn L. Erb, Kayla A. Sipple, Nathan D. Levine…·Darren J. Moore

This study shows that deleting ATP13A2 in adult mice leads to progressive dopaminergic degeneration and lysosomal issues, mimicking human neurodegenerative diseases.

20 citationstop 3%

mouseexperimental assay

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NeuroscienceMolecular NeurodegenerationPeer-reviewedJun 11, 2024

Single molecule array measures of LRRK2 kinase activity in serum link Parkinson's disease severity to peripheral inflammation

Yuan Yuan, Huizhong Li, Kashyap Sreeram…·Andrew B. West

The paper measures LRRK2 kinase activity via pT73-Rab10 in serum, linking it to inflammation and Parkinson's disease severity.

21 citationstop 3%

mouserat

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