Loss of heterozygosity exposes germline mutations in complex I and drives Warburg metabolism in oncocytic carcinoma of the thyroid
Celia de la Calle Arregui, Anderson R. Frank, Kelvin Mun, Jiwoong Kim, Kuntal Majmudar, Justin A. Bishop, Cheryl M. Lewis, Yang Xie, David G. McFadden
The paper identifies germline mutations in complex I subunits as a driver of Warburg metabolism in oncocytic thyroid carcinoma through loss of heterozygosity.
Science Advances · Jul 3, 2026Peer-reviewedCancer Biology