Cheryl M. Lewis

The paper identifies germline mutations in complex I subunits as a driver of Warburg metabolism in oncocytic thyroid carcinoma through loss of heterozygosity.

This study identifies biomechanical stiffening and fibrotic remodeling as hallmarks of early-onset colorectal cancer, showing their role in tumor initiation.

This study shows that CDK6's non-kinase function drives resistance to CDK4/6 inhibitors in ER+ breast cancer, challenging the assumption that kinase inhibition is the main therapeutic target.

This paper identifies geometric and spatial patterns in pancreatic cancer that correlate with aggressive behavior and develops an AI tool to improve clinical evaluation and treatment planning.

The paper shows that the integrated stress response (ISR) coordinates the translation of PD-L1 and CD155, two immune checkpoint proteins, in lung cancer, and suggests combining ISR inhibition with PD-1 blockade as a therapeutic strategy.