Novel high throughput 3D ECM remodeling assay identifies MEK as key driver of fibrotic fibroblast activity
Chen‐Yi Liao, Jasmijn H.M. Hundscheid, Justin Crawford, Peter ten Dijke, Beatrice Coornaert, Erik H.J. Danen
The paper develops a high-throughput 3D ECM remodeling assay to identify MEK as a key driver of fibrotic fibroblast activity, showing that MEK-ERK signaling, not TGFβ signaling, drives ECM remodeling.
Materials Today Bio · Apr 24, 2025Peer-reviewedCell Biology