Peter ten Dijke

Label-free Isolation of Heterogeneous Breast Cancer Cell Populations via Insulator-Based Dielectrophoresis

This paper develops a microfluidic platform using insulator-based dielectrophoresis to isolate breast cancer cells from blood with high recovery and purity.

Transient suppression of the ECM1 gatekeeper is essential for HGF/c-MET-driven liver regeneration

This study identifies ECM1 as a gatekeeper that transiently suppresses HGF activity during liver regeneration, enabling tissue repair through c-MET-ERK-MYC signaling.

Decoding the Mechanism of Action of a Parasite TGFβAntagonist Inspires the Creation of Cell-type-specific TGFβ Modulators

This paper identifies co-receptors for a parasite TGFβ antagonist, uses structural data to design cell-type-specific TGFβ modulators, and demonstrates their selective antagonistic effects.

Pro-domain-dependent folding and co-receptor-mediated targeting to optimize an antagonistic TGF-β monomer for gene-based delivery

This paper improves the folding and targeting of an engineered TGF-β monomer for gene-based delivery by modifying its pro-domain and adding a CD44 binding domain.

Inter-Spheroid Proximity and Matrix Remodeling Determine CAF-Mediated Cancer Cell Invasion

This study investigates how CAFs drive cancer cell invasion through matrix remodeling and inter-spheroid proximity in a 3D in vitro model of Luminal A breast cancer.

Novel high throughput 3D ECM remodeling assay identifies MEK as key driver of fibrotic fibroblast activity

The paper develops a high-throughput 3D ECM remodeling assay to identify MEK as a key driver of fibrotic fibroblast activity, showing that MEK-ERK signaling, not TGFβ signaling, drives ECM remodeling.

Automated microinjection for zebrafish xenograft models

This paper develops an automated microinjection robot for zebrafish xenograft models, achieving 60% success rate and 70% survival rate, with twice the speed of manual injections.

EMT-dependent cell-matrix interactions are linked to unjamming transitions in cancer spheroid invasion

This study investigates how EMT-dependent cell-matrix interactions influence unjamming transitions in cancer spheroid invasion using 3D invasion assays and quantitative image analysis.

Balance Between EGF/STAT1 and IFNγ/NRF2 Signaling Controls ECM1 Expression and Determines Hepatic Homeostasis versus Chronic Liver Disease

This study identifies EGF/STAT1 and IFNγ/NRF2 signaling pathways regulating ECM1 expression, showing their role in maintaining liver homeostasis versus promoting chronic liver disease.