Erik H.J. Danen

Septins promote breast cancer cell invasion in 3D collagen gels by influencing actin-based protrusion formation

This study shows that SEPT7 depletion reduces breast cancer cell invasion in 3D collagen gels by affecting actin-based protrusions and cell shape.

Informing agent-based models with spatial data using convolutional autoencoders

This paper presents a framework to optimize agent-based models using spatial data by comparing imaging data and model outputs in a shared latent space, showing improved reproduction of spatial features.

Multi-omics characterization of breast cancer metabolism identifies new metabolic targets

This study identifies metabolic targets in breast cancer by analyzing multi-omics data from cell lines, revealing subtype-specific dependencies and potential drug targets.

Disentangling the interplay between cell-cell and cell-matrix interactions in cancer cell migration

This study combines experimental and computational approaches to understand how cell-cell and cell-matrix interactions influence cancer cell invasion and metastasis.

Matrix stiffness affects spheroid invasion, collagen remodeling and the effective reach of stress into the ECM.

This study investigates how matrix stiffness influences spheroid invasion, collagen remodeling, and stress propagation in the ECM using 3D spheroids and stress sensors.

Novel high throughput 3D ECM remodeling assay identifies MEK as key driver of fibrotic fibroblast activity

The paper develops a high-throughput 3D ECM remodeling assay to identify MEK as a key driver of fibrotic fibroblast activity, showing that MEK-ERK signaling, not TGFβ signaling, drives ECM remodeling.

Altered Mechanobiology of PDAC Cells with Acquired Chemoresistance to Gemcitabine and Paclitaxel.

This study investigates altered mechanobiology in PDAC cells with acquired chemoresistance to gemcitabine and paclitaxel, finding increased traction forces and altered motility and invasion.