T Cell Receptors for Antigen on Intraepitheial Cytolytic T Lymphocytes in Celiac Disease Engage Enterocyte HLA-E and HLA-B
Justin E. Johnson, Kriti Agrawal, Rafia S. Al‐Lamki, Fengrui Zhang, Xi D. Wang, Zuzana Tobiásová, Shakila Afroz Taleb, Samuel T. Liburd, Leonel Rodriguez, Andrew J. Martins, Richard Anthony Flavell, Marie E. Robert, Esen Sefik, Jordan S. Pober
This study identifies IFNγ-producing intraepithelial CTLs in celiac disease that interact with HLA-E/B on enterocytes, promoting CTL recruitment and epithelial killing.
Proceedings of the National Academy of Sciences · Feb 5, 2026Peer-reviewedImmunology