Jordan S. Pober

This study shows simvastatin preserves endothelial barrier function by modulating RhoB localization and activation through mevalonate-dependent mechanisms during TNF stimulation.

This study identifies oncostatin M-driven vascular leak in human endothelial cells through nanoscale channel formation, distinct from junction disassembly, and highlights potential therapeutic targets.

Regulon-based clustering of islet scRNA-seq finds an IRF1-high, cytokine-driven beta cell state with reduced identity and autoantigen genes, enriched in type 1 diabetes donors.

The study shows that endothelial cell MHC molecules are critical for rejecting 3D-printed human skin grafts in an immunocompetent humanized mouse model.

This study identifies IFNγ-producing intraepithelial CTLs in celiac disease that interact with HLA-E/B on enterocytes, promoting CTL recruitment and epithelial killing.

This study identifies a T-cell intrinsic mechanism by which APOL1 risk alleles contribute to kidney rejection through altered calcium signaling and T-cell activation.