Richard Anthony Flavell

This study uses reverse genetics in humanized mice to show that DPP9 deficiency causes CARD8-mediated pyroptosis in human hematopoietic stem and progenitor cells, leading to pancytopenia.

This study shows that TIF1γ maintains T regulatory cell stability and suppressor function during inflammation by regulating Foxp3 expression and the beta-catenin pathway.

The study shows that endothelial cell MHC molecules are critical for rejecting 3D-printed human skin grafts in an immunocompetent humanized mouse model.

This study shows that inhibiting DNMT1 improves CD8+ T cell function in the tumor microenvironment and enhances the effectiveness of immune checkpoint inhibitors in a melanoma model.

The paper identifies DPP9 as a genetic susceptibility gene for checkpoint inhibitor pneumonitis and shows IL-18 blockade could be a therapeutic strategy.

This study uses gene-edited hematopoietic stem cells to create long-lived B lymphocyte protein factories that produce therapeutic antibodies against HIV-1, malaria, and influenza.

This study identifies IFNγ-producing intraepithelial CTLs in celiac disease that interact with HLA-E/B on enterocytes, promoting CTL recruitment and epithelial killing.

This study shows Borrelia burgdorferi binds serum amyloid A and modulates immune signaling in subcutaneous adipose tissue, identifying SAA as a host defense factor.

This study identifies IL-18 as a critical factor produced by pregnant uterine smooth muscle cells that supports placental development and fetoplacental growth, with implications for maternal and fetal health.

This study shows FABP5 regulates ether lipid metabolism, reducing inflammation in atopic dermatitis by modulating platelet activating factor levels.

This study shows that linker histone H1.0 regulates HSPC fate bias toward lymphoid or myeloid differentiation, with H1.0 levels decreasing in response to IFN signaling.

This study shows IL-4 promotes B cell activation by upregulating cholesterol synthesis, which is essential for ER expansion, cell cycle progression, and proliferation during influenza infection.

GeneTrajectory infers gene trajectories instead of cell trajectories to uncover progressive gene dynamics in biological processes.

This paper introduces scShift, a deep variational model that enables zero-shot characterization of single-cell biological states across datasets by overcoming batch effects.

DA-seq identifies differentially abundant cell subpopulations between biological states in scRNA-seq data, revealing both known and novel subpopulations with biological insights.