Nascent matrix deposition supports alveolar organoid formation from aggregates in synthetic hydrogels
Madeline K. Eiken, Charlie J. Childs, Lindy K. Brastrom, Tristan Frum, Eleanor M. Plaster, Donia W Ahmed, Ryan C. Spencer, Orren Shachaf, Suzanne Pfeiffer, Justin E. Levine, Konstantinos–Dionysios Alysandratos, Darrell N. Kotton, Jason R. Spence, Claudia Loebel
This study develops a Matrigel-free method using synthetic hydrogels to form alveolar organoids, showing they secrete their own extracellular matrix for growth.
Stem Cell Reports · Dec 12, 2024Peer-reviewedCell Biology