Author

Justin T. Seffernick

St. Jude Children's Research Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Anand Mayasundari· 1 shared Angelina Li· 1 shared Anup AggarwaliD· 1 shared Dong Geun LeeiD· 1 shared Gisele NishiguchiiD· 1 shared Jamie JarusiewicziD· 1 shared Jun J Yang· 1 shared Lei YangiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Anand Mayasundari

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1 paper

Recent·Most cited

LCK-targeting molecular glues overcome resistance to inhibitor-based therapy in T-cell acute lymphoblastic leukemia

Jun J Yang, Gisele Nishiguchi, Satoshi Yoshimura, Marisa Actis, Justin T. Seffernick, Jamie Jarusiewicz, Anup Aggarwal, Angelina Li, Yong Li, Dong Geun Lee, Lei Yang, Anand Mayasundari, Zoran Ranković, Marcus M. Fischer

This study develops LCK-targeting molecular glues that overcome resistance to kinase inhibitors in T-ALL by inducing CRBN-dependent degradation of LCK.

bioRxiv · Jul 3, 2025 · PreprintCancer Biology