Author

Jun J Yang

St. Jude Children's Research Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1

Frequent Co-Authors

Anand Mayasundari· 1 shared Angelina Li· 1 shared Anup AggarwaliD· 1 shared Brett Brown· 1 shared Charles Grenfell MullighaniD· 1 shared Damilola OluwalanaiD· 1 shared Daniel SaviciD· 1 shared David T Teachey· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperCancer Biology

Anand Mayasundari

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Glucocorticoid receptor activation reorganizes Wnt/LEF1 regulatory circuitry associated with therapeutic response in B-cell acute lymphoblastic leukemia

Robert J. Mobley, Damilola Oluwalana, Gabriele Baniulyte, Minzhang Zheng, Brett Brown, Faten Usrof, Kashi Raj Bhattarai, Kelly R. Barnett, Virginia A. Valentine, Marcus L Valentine, Seth Staller, Satoshi Yoshimura, Kristine R. Crews, David T Teachey, Steven Burden, , Daniel Savic

This study shows that GR activation reorganizes Wnt/LEF1 regulatory circuitry in B-ALL, influencing therapeutic response and resistance through chromatin state changes and gene regulation.

bioRxiv · Sep 24, 2026 · PreprintCancer Biology

The Genomic Architecture of Human DNA Replication Origins

Zhenhua Li, Wenjian Yang, Gang Wu, Satoshi Yoshimura, Charles Grenfell Mullighan, Tracie C. Rosser, Elizabeth J. Leslie, Karen R. Rabin, Philip J. Lupo, David T. Teachey, Jun J Yang

The paper maps human DNA replication origins using whole-genome sequencing data, identifying a 16 bp motif and periodicity, and links replication activity to gene expression and genetic variation.

bioRxiv · Nov 29, 2025 · PreprintCell Biology

LCK-targeting molecular glues overcome resistance to inhibitor-based therapy in T-cell acute lymphoblastic leukemia

Jun J Yang, Gisele Nishiguchi, Satoshi Yoshimura, Marisa Actis, Justin T. Seffernick, Jamie Jarusiewicz, Anup Aggarwal, Angelina Li, Yong Li, Dong Geun Lee, Lei Yang, Anand Mayasundari, Zoran Ranković, Marcus M. Fischer

This study develops LCK-targeting molecular glues that overcome resistance to kinase inhibitors in T-ALL by inducing CRBN-dependent degradation of LCK.

bioRxiv · Jul 3, 2025 · PreprintCancer Biology