Ketone body mediated histone β-hydroxybutyrylation is reno-protective
Juthika Mandal, Sachin Aryal, Ishan Manandhar, Saroj Chakraborty, Xue Mei, Beng San Yeoh, Blair Mell, Andrew L. Kleinhenz, Ramakumar Tummala, Tao Yang, Piu Saha, William T. Gunning, Matam Vijay–Kumar, Venkatesha Basrur, Ivana L. de la Serna, Bina Joe
This study shows that ketone body-mediated histone β-hydroxybutyrylation in the kidney regulates chromatin structure to promote energy metabolism and suppress immune responses, offering renoprotection.
Hypertension · Jul 29, 2025Peer-reviewedPhysiology