Ivana L. de la Serna

This study identifies intestinal serotonergic vagal signaling as a key mediator of microbiota-induced hypertension, showing that reduced 5-HT and 5HT3aR signaling contributes to hypertension and can be reversed to alleviate it.

This paper shows YAP1 promotes therapy resistance in melanoma by altering chromatin structure and immune evasion programs, and suggests TEAD inhibitors could overcome resistance and boost immune response.

This study shows that ketone body-mediated histone β-hydroxybutyrylation in the kidney regulates chromatin structure to promote energy metabolism and suppress immune responses, offering renoprotection.

This study shows that ablating the Atp1b4 gene in mice reduces obesity and improves metabolic parameters by disrupting evolutionarily acquired BetaM functions.