Author

Ishan Manandhar

University of ToledoORCID 0000-0001-6772-2540Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Beng San YeohiD· 2 shared Bina JoeiD· 2 shared Blair MelliD· 2 shared Matam Vijay–KumariD· 2 shared Piu SahaiD· 2 shared Ramakumar TummalaiD· 2 shared Sachin AryaliD· 2 shared Xue MeiiD· 2 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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2 shared papersPhysiology

Beng San YeohORCID

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2 papers

Recent·Most cited

PhysiologybioRxivPreprintFeb 27, 2026

The Herbicide Glyphosate Promotes Hypertension via Gut Microbiota-Mediated Mechanisms

Ishan Manandhar, Sudhan Pachhain, Ramakumar Tummala…·Bina Joe

This study shows glyphosate exposure increases blood pressure through gut microbiota-mediated disruption of FXR-signaling and shikimic acid accumulation.

DOI 10.64898/2026.02.25.708064

humanmetagenomics

𝕏 PostBluesky

PhysiologyHypertensionPeer-reviewedJul 29, 2025

Ketone body mediated histone β-hydroxybutyrylation is reno-protective

Juthika Mandal, Sachin Aryal, Ishan Manandhar…·Bina Joe

This study shows that ketone body-mediated histone β-hydroxybutyrylation in the kidney regulates chromatin structure to promote energy metabolism and suppress immune responses, offering renoprotection.

7 citations

mouseChIP-seq

𝕏 PostBluesky