Loss of function from widely distributed, synonymous mutations at single codons
Kritika Gupta, Jyothi Prabha, Soumyanetra Chandra, Shruti Khare, Sonali Vishwa Mohan, Pehu Kohli, Aparna Asok, Harsha Gowda, Arati Ramesh, Raghavan Varadarajan
The paper shows that synonymous mutations can cause loss of function by altering RNA structure and gene expression ratios, validated in multiple operons.
bioRxiv · Jul 2, 2019 · PreprintMolecular Biology