Author

Aparna Asok

Indian Institute of Science Bangalore

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:proteomics· 2 Research Focus:differential expression· 1 Organism:E. coli· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

Raghavan VaradarajaniD· 3 shared Harsha GowdaiD· 2 shared Kritika GuptaiD· 2 shared Pehu KohliiD· 2 shared Shruti KhareiD· 2 shared Sonali Vishwa MohaniD· 2 shared Soumyanetra ChandraiD· 2 shared Arati RameshiD· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersMolecular Biology

Raghavan VaradarajanORCID

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3 papers

Recent·Most cited

Charged Scanning Mutagenesis as a High Throughput Approach for Epitope Mapping

Kawkab Kanjo, Munmun Bhasin, Chandrani Dey, Navid Bakshi, Aparna Asok, Randhir Kumar Singh, Sahil Kumar, Rajesh P. Ringe, Raghavan Varadarajan

This study introduces a high-throughput method for epitope mapping using charged scanning mutagenesis and flow cytometry, identifying epitopes in SARS-CoV-2 RBD targeted by polyclonal sera.

Protein Science · Dec 22, 2025Peer-reviewedBiophysics

The high mutational sensitivity of ccdA antitoxin is linked to codon optimality

Soumyanetra Chandra, Kritika Gupta, Shruti Khare, Pehu Kohli, Aparna Asok, Sonali Vishwa Mohan, Harsha Gowda, Raghavan Varadarajan

The paper shows that ccdA antitoxin in E. coli is highly sensitive to mutations, including synonymous ones, due to codon usage and operonic context effects on translation efficiency.

Molecular Biology and Evolution · Sep 5, 2022Peer-reviewedMolecular Biology

Loss of function from widely distributed, synonymous mutations at single codons

Kritika Gupta, Jyothi Prabha, Soumyanetra Chandra, Shruti Khare, Sonali Vishwa Mohan, Pehu Kohli, Aparna Asok, Harsha Gowda, Arati Ramesh, Raghavan Varadarajan

The paper shows that synonymous mutations can cause loss of function by altering RNA structure and gene expression ratios, validated in multiple operons.

bioRxiv · Jul 2, 2019 · PreprintMolecular Biology