Author

Kritika Gupta

Indian Institute of Science BangaloreORCID 0000-0002-4982-2342Unclaimed ORCID profile · follow to get notified of new preprints

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Kritika Gupta1 paper

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:differential expression· 1 Organism:E. coli· 1 Assay:proteomics· 1

Frequent Co-Authors

Aparna Asok· 2 shared Harsha GowdaiD· 2 shared Pehu KohliiD· 2 shared Raghavan VaradarajaniD· 2 shared Shruti KhareiD· 2 shared Sonali Vishwa MohaniD· 2 shared Soumyanetra ChandraiD· 2 shared Arati RameshiD· 1 shared

Activity by Year

2019-2022 · peak 1/yr

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9 top collaborators · 36 mutual co-author links

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2 shared papersMolecular Biology

Aparna Asok

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2 papers

Recent·Most cited

Molecular BiologyMolecular Biology and EvolutionPeer-reviewedSep 5, 2022

The high mutational sensitivity of ccdA antitoxin is linked to codon optimality

Soumyanetra Chandra, Kritika Gupta, Shruti Khare…·Raghavan Varadarajan

The paper shows that ccdA antitoxin in E. coli is highly sensitive to mutations, including synonymous ones, due to codon usage and operonic context effects on translation efficiency.

14 citations

E. coliproteomics

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Molecular BiologybioRxivPreprintJul 2, 2019

Loss of function from widely distributed, synonymous mutations at single codons

Kritika Gupta, Jyothi Prabha, Soumyanetra Chandra…·Raghavan Varadarajan

The paper shows that synonymous mutations can cause loss of function by altering RNA structure and gene expression ratios, validated in multiple operons.

DOI 10.1101/684092

experimental assay

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