Contribution of Wide Dynamic Range neuronal activation to somatosensory evoked potentials supports use as biomarker of spinal nociceptive processing
Kenneth A Steel, Tony Blockeel, Elise A. Ajay, Jeffrey L. Krajewski, K Phillips, James Dunham, Anthony Edward Pickering
The paper identifies WDR neuron inhibition as the mechanism by which tapentadol modulates spinal SEPs, supporting their use as a biomarker of spinal nociceptive processing.
bioRxiv · Jul 21, 2026 · PreprintNeuroscience