Anthony Edward Pickering

This study shows that silent nociceptors are active during both phases of the formalin test in rats, suggesting their involvement in persistent pain mechanisms.

The paper identifies WDR neuron inhibition as the mechanism by which tapentadol modulates spinal SEPs, supporting their use as a biomarker of spinal nociceptive processing.

This paper develops mechanically stable multi-electrode neural probes for high-resolution, multichannel recordings in peripheral nerves, improving signal yield and performance compared to single-electrode probes.

This study assesses the effects of lacosamide, pregabalin, and tapentadol on the rat spinal N1 somatosensory evoked potential to evaluate their analgesic mechanisms.

This study induces synthetic torpor in rats and shows it reduces heart damage from ischaemia-reperfusion injury by ~40%.

The paper shows that the dorsal vagal complex has circadian rhythms regulated by meal timing, with clock genes and their targets expressed rhythmically in vivo.

This study analyzes LC neuron firing patterns across species and biological factors, revealing diverse activity patterns and subregions enriched for specific factors and disease models.

This study investigates how noradrenaline release within the Locus Coeruleus modulates cross-modular interactions through reciprocal inhibition and rebound activity.

This study identifies DMH neurons active during torpor in mice and shows they promote and prolong torpor, but are not sufficient for its initiation.

The paper uses pharmacological-fMRI to show that attentional analgesia in humans is mediated by opioidergic pathways from ACC to PAG and RVM, which suppress spinal nociceptive activity.

The paper uses machine learning to analyze single-trial laser evoked potentials (LEPs) in rats, identifying distinct Aδ- and C-fibre mediated responses that predict pain behavior.

The paper replicates and extends previous findings on attentional analgesia by identifying two parallel cortico-brainstem pathways modulated by attentional demand.

This study shows that locus-coeruleus norepinephrine activity determines the likelihood of sensory-evoked awakenings from sleep, with reduced activity during sleep suppressing responses to auditory stimuli.

This study shows that astrocytes in the brainstem dorsal vagal complex regulate food intake by inhibiting appetite through a circuit without causing aversion.

The paper investigates Barrington’s nucleus corticotrophin-releasing hormone neurons in mice, showing they provide probabilistic control over bladder contractions and micturition through opto- and chemo-genetic manipulations.

This paper models the locus coeruleus (LC) and noradrenaline (NA) system using Active Inference to show that LC activity reflects prediction errors, enabling adaptive learning and cognitive flexibility.

The paper shows that spinal and prefrontal projecting locus coeruleus neurons in rats mediate distinct pain-related behaviors: analgesia vs. aversion and anxiety.