Jeffrey L. Krajewski

The paper identifies WDR neuron inhibition as the mechanism by which tapentadol modulates spinal SEPs, supporting their use as a biomarker of spinal nociceptive processing.

The paper investigates the expression and localization of NMDA receptor GluN2 subunits in dorsal horn pain circuits across sex, species, and development, finding conserved expression but species- and development-specific localization patterns.

This paper describes a protocol for preparing viable human spinal cord slices for acute electrophysiological recordings to bridge the translational gap between rodent models and human patients.

This study assesses the effects of lacosamide, pregabalin, and tapentadol on the rat spinal N1 somatosensory evoked potential to evaluate their analgesic mechanisms.

The paper compares NMDA receptor decay kinetics in lamina I pain neurons across sex and species, finding conserved heterogeneity but species-specific differences in subunit contributions.

This study investigates the effects of inhibiting specific voltage-gated sodium channel isoforms on epileptiform activity in mouse cortical slices, finding that Nav1.6 inhibition is more effective than Nav1.1 inhibition.