Deep mutational scanning of hemagglutinin helps predict evolutionary fates of human H3N2 influenza variants
J. M. Lee, J. Huddleston, M. B. Doud, K. A. Hooper, N. C. Wu, T. Bedford, J. D. Bloom
The paper experimentally measures the effects of all single amino-acid mutations in H3N2 influenza HA on viral growth and shows their correlation with evolutionary success in natural lineages.
bioRxiv · Apr 10, 2018Evolutionary Biology