Author

K. A. Schleyer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 4

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 1 Assay:fluorescence / live-cell microscopy· 1 Organism:human· 1

Frequent Co-Authors

L. Cui· 4 shared J. Liu· 3 shared B. Fetrow· 2 shared C. Cui· 2 shared P. Z. Fatland· 2 shared A. Kafle· 1 shared B. Burnside· 1 shared B. D. Datko· 1 shared

Activity by Year

2020-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersBiochemistry

L. Cui

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A self-immolative linker for heparanase activatable probe

K. A. Schleyer, J. Liu, Z. Wang, L. Cui

This paper introduces a self-immolative linker that restores activity to an inactive heparanase probe, enabling facile development of activatable imaging probes.

bioRxiv · Jun 15, 2021 · PreprintBiochemistry

Internally quenched fluorogenic probe provides selective and rapid detection of cathepsin L activity

K. A. Schleyer, B. Fetrow, P. Z. Fatland, J. Liu, M. Chaaban, B. Ma, L. Cui

The paper introduces CTLAP, a fluorogenic probe that selectively and rapidly detects cathepsin L activity with improved selectivity and turn-on ratio compared to existing probes.

bioRxiv · Mar 28, 2020Biochemistry

Ultrasensitive small molecule fluorogenic probe for human heparanase

J. Liu, K. A. Schleyer, T. L. Bryan, C. Xie, G. Seabra, Y. Xu, A. Kafle, C. Cui, Y. Wang, K. Yin, B. Fetrow, P. K. P. Henderson, P. Z. Fatland, J. Liu, C. Li, , L. Cui

This paper introduces an ultrasensitive fluorogenic probe for detecting human heparanase activity with a picomolar detection limit and demonstrates its use in high-throughput inhibitor screening.

bioRxiv · Mar 26, 2020Biochemistry

Responsive fluorophore aggregation provides spectral contrast for fluorescence lifetime imaging

K. A. Schleyer, B. D. Datko, B. Burnside, C. Cui, X. Ma, J. K. Grey, L. Cui

The paper develops a fluorescent probe that changes emission lifetime upon aggregation, demonstrating potential for responsive imaging probes.

bioRxiv · Jan 28, 2020Biochemistry