K. Yin

Systematic annotation of orphan RNAs reveals blood-accessible molecular barcodes of cancer identity and cancer-emergent oncogenic drivers

The paper systematically identifies and characterizes cancer-emergent oncRNAs across 32 tumor types, showing they act as blood-accessible molecular barcodes for cancer identity and prognosis.

Single-nucleus Multiomic Analyses Identifies Gene Regulatory Dynamics of Phenotypic Modulation in Human Aneurysmal Aortic Root

This study uses single-nucleus multiomic and spatial transcriptomic data to identify gene regulatory dynamics and key regulators in human aortic root tissue under healthy and Marfan syndrome conditions.

Post-acute immunological and behavioral sequelae in mice after Omicron infection

This study investigates post-acute immunological and behavioral effects in mice after Omicron infection, showing vaccination reduces pulmonary immune perturbations and behavioral deficits.

Integrative identification of non-coding regulatory regions driving metastatic prostate cancer

This study identifies non-coding regulatory regions driving metastatic prostate cancer using an integrative computational and experimental approach.

Inhibition of muscarinic receptor signaling protects human enteric inhibitory neurons against platin chemotherapy toxicity

This study identifies muscarinic receptor signaling as a key driver of platin-induced enteric neuropathy and shows that its inhibition protects neurons from toxicity.

Long COVID manifests with T cell dysregulation, inflammation, and an uncoordinated adaptive immune response to SARS-CoV-2

This study identifies T cell dysregulation, inflammation, and mis-coordinated adaptive immune responses in Long COVID patients compared to non-LC individuals.

Label-free quantitative proteomics analyses of mouse astrocytes provides insight into the host response mechanism at different developmental stages of Toxoplasma gondii

This study uses label-free proteomics to analyze mouse astrocytes infected with different stages of Toxoplasma gondii, identifying differentially expressed proteins that reveal host response mechanisms in acute and chronic infections.

Structural basis for the neurotropic AAV9 and the engineered AAVPHP.eB recognition with cellular receptors

This study determines the cryo-EM structures of AAV9 and AAVPHP.eB in complex with their receptor AA VR, revealing molecular details of receptor recognition and explaining enhanced CNS transduction.

Hepatocyte-specific activity of TSC22D4 triggers progressive NAFLD by impairing mitochondrial function

This study shows that deleting TSC22D4 in hepatocytes reduces liver damage in NASH by improving mitochondrial function and lipid metabolism.

Lineage-specific regulatory changes in the pathological cardiac remodeling of hypertrophy cardiomyopathy unraveled by single-nucleus RNA-seq and spatial transcriptomics

This study uses single-nucleus RNA-seq and spatial transcriptomics to identify lineage-specific regulatory changes and candidate therapeutic targets in hypertrophy cardiomyopathy.

Small-molecule cocktails induce the differentiation of human adipose-derived mesenchymal stem cells into hepatocyte-like cells

This study induces human adipose-derived mesenchymal stem cells into hepatocyte-like cells using small-molecule cocktails and growth factors, producing cells with mature phenotype and function.

Ultrasensitive small molecule fluorogenic probe for human heparanase

This paper introduces an ultrasensitive fluorogenic probe for detecting human heparanase activity with a picomolar detection limit and demonstrates its use in high-throughput inhibitor screening.

Dynamic aqueous multiphase reaction system for simple, sensitive and quantitative one-pot CRISPR-Cas12a based molecular diagnosis

This paper introduces a dynamic aqueous multiphase reaction system for rapid, sensitive, and quantitative CRISPR-Cas12a-based molecular diagnosis of HPV16/18 DNA.

All-in-One Dual CRISPR-Cas12a (AIOD-CRISPR) Assay: A Case for Rapid, Ultrasensitive and Visual Detection of Novel Coronavirus SARS-CoV-2 and HIV virus

The paper introduces AIOD-CRISPR, a dual CRISPR-Cas12a assay for rapid, ultrasensitive, and visual detection of SARS-CoV-2 and HIV with high sensitivity comparable to RT-PCR.

A screening platform based on epitope editing for drug discovery

This paper introduces a drug discovery platform called SPEED that uses epitope editing to screen small molecules for altering antibody-epitope interactions and validates its application for Aβ species.