Ultrasensitive small molecule fluorogenic probe for human heparanase
J. Liu, K. A. Schleyer, T. L. Bryan, C. Xie, G. Seabra, Y. Xu, A. Kafle, C. Cui, Y. Wang, K. Yin, B. Fetrow, P. K. P. Henderson, P. Z. Fatland, J. Liu, C. Li, , L. Cui
This paper introduces an ultrasensitive fluorogenic probe for detecting human heparanase activity with a picomolar detection limit and demonstrates its use in high-throughput inhibitor screening.
bioRxiv · Mar 26, 2020Biochemistry