Novel inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives
K. Amporndanai, X. Meng, H. Yang, Z.-J. Liu, L. Zhang, Y. Zhao, S. Hasnain, P. O'Neill, Z. Rao, Z. Jin, W. Shang
This study identifies a novel inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives through crystallography and mass spectrometry, revealing a unique covalent adduct formation and by-product generation.
bioRxiv · Mar 11, 2021Biophysics