W. Shang

mRNA targeting eliminates the need for the signal recognition particle during membrane protein insertion in bacteria

The paper shows that mRNA targeting can replace the SRP pathway for membrane protein insertion in bacteria, using in vivo and in vitro assays.

Planting graphene quantum dots in PEGylated nanoparticles for enhanced and multimodal in vivo imaging of tumor

This study implants graphene quantum dots in PEGylated nanoparticles to enhance in vivo imaging and tumor detection, showing improved circulation and tumor accumulation.

Sub-cellular dynamic investigation of the multi-component drug on the gastric cancer cell BGC823 using Raman spectroscopy

This study uses micro-Raman spectroscopy to investigate sub-cellular changes in gastric cancer cells treated with a multi-component drug, revealing effects on DNA replication, vesicle dynamics, and lipid levels.

Novel inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives

This study identifies a novel inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives through crystallography and mass spectrometry, revealing a unique covalent adduct formation and by-product generation.

Novel and potent inhibitors targeting DHODH, a rate-limiting enzyme in de novo pyrimidine biosynthesis, are broad-spectrum antiviral against RNA viruses including newly emerged coronavirus SARS-CoV-2

This paper identifies two potent DHODH inhibitors with broad-spectrum antiviral activity against RNA viruses, including SARS-CoV-2, and suggests their potential clinical use.

Structure Basis for Inhibition of SARS-CoV-2 by the Feline Drug GC376

The paper determines the structure of SARS-CoV-2 Mpro and shows how GC376 inhibits its catalytic site, supporting its use as an antiviral drug.

Broad-spectrum antivirals of protoporphyrins inhibit the entry of highly pathogenic emerging viruses

This study identifies a protoporphyrin derivative that inhibits entry of enveloped viruses by targeting viral lipids, showing broad antiviral activity in vitro and in vivo.

Immunoglobulin fragment F(ab')2 against RBD potently neutralizes SARS-CoV-2 in vitro

This study produces and tests an F(ab')2 fragment against SARS-CoV-2 RBD, showing potent in vitro neutralization with an EC50 of 0.07 g/ml.

β-lactam Antibiotics Stimulate the Pathogenicity of Methicillin-resistant Staphylococcus aureus Via SarA-controlled Tandem Lipoprotein Expression

This study shows that β-lactam antibiotics increase MRSA pathogenicity by upregulating the tlpps gene cluster via SarA, leading to enhanced inflammation and infection severity.