Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
10 papers
Recent·Most cited
Q. Liu, Y. Shang, Z. Tao, X. Li, L. Shen, H. Zhang, Z. Liu, Z. Rao, X. Yu, Y. Cao, L. Zeng, X. Huang
This study shows CVB3 infection upregulates ASS1 through citrulline consumption, leading to metabolic reprogramming and macrophage inflammatory polarization, contributing to viral myocarditis.
bioRxiv · May 8, 2024Microbiology
J. Yang, S. Zou, Z. Qiu, M. Lai, Q. Long, H. Chen, P. Lai, S. Zhang, Z. Rao, X. Xie, Y. Gong, A. Liu, M. Li, X. Bai
This study shows Mecp2 negatively regulates quiescence exit by activating metabolic genes and repressing proliferation genes, with nuclear receptors Rara and Nr1h3 playing a key role.
bioRxiv · Jul 24, 2023Cell Biology
S. Zhou, W. Wang, X. Zhou, Y. Zhang, Y. Lai, Y. Tang, J. Xu, X. Yang, L. W. Guddat, Q. Wang, Y. Gao, Z. Rao, H. Gong
The paper reports the structures of M. tuberculosis cytochrome bcc complexed with two anti-TB drugs, revealing binding sites and interactions that inform inhibitor design.
bioRxiv · Jun 15, 2021Microbiology
K. Amporndanai, X. Meng, H. Yang, Z.-J. Liu, L. Zhang, Y. Zhao, S. Hasnain, P. O'Neill, Z. Rao, Z. Jin, W. Shang
This study identifies a novel inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives through crystallography and mass spectrometry, revealing a unique covalent adduct formation and by-product generation.
bioRxiv · Mar 11, 2021Biophysics
X. Wang, C. Qin, Y. Wang, Z. Rao, L. Xie, L. Zhu, Y.-Q. Deng, R.-r. Zhang, Z. Cui, C.-Y. Sun, C.-F. Fan, X. Xing, W. Huang, Q. Chen, N.-N. Zhang, , J. Hu
This paper identifies and characterizes a potent human monoclonal antibody, HB27, that blocks SARS-CoV-2 receptor binding and membrane fusion, showing protective effects in mice and non-adverse effects in rhesus macaques.
bioRxiv · Nov 24, 2020 · PreprintBiophysics
Z. Lv, Y.-Q. Deng, Q. Ye, L. Cao, C.-Y. Sun, C. Fan, W. Huang, S. Sun, Y. Sun, L. Zhu, Q. Chen, N. Wang, J. Nie, Z. Cui, D. Zhu, , X. Wang
A potent neutralizing antibody protected against SARS-CoV-2 in an hACE2 mouse model by blocking viral receptor interaction.
Science · Sep 18, 2020Peer-reviewedBiophysics
Z. Jin, Y. Zhao, Y. Sun, B. Zhang, H. Wang, Y. Wu, Y. Zhu, C. Zhu, T. Hu, X. Du, Y. Duan, J. Yu, X. Yang, X. Yang, K. Yang, , Z. Rao
This study shows Carmofur inhibits SARS-CoV-2 main protease by covalently binding to Cys145 and occupying the S2 subsite, with an EC50 of 24.30 M in cell-based viral replication assays.
bioRxiv · Apr 9, 2020Biochemistry
W. Dai, B. Zhang, X.-M. Jiang, H. Su, J. Li, Y. Zhao, X. Xie, Z. Jin, J. Peng, F. Liu, C. Li, Y. Li, F. Bai, H. Wang, X. Cheng, , H. Liu
This study designs, synthesizes, and evaluates two peptidomimetic aldehydes as antiviral drug candidates targeting SARS-CoV-2 main protease, showing potent inhibition and anti-infection activity.
bioRxiv · Mar 25, 2020 · PreprintBiochemistry
Y. Gao, L. Yan, Y. Huang, F. Liu, Y. Zhao, L. Cao, T. Wang, Q. Sun, Z. Ming, L. Zhang, J. Ge, L. Zheng, Y. Zhang, H. Wang, Y. Zhu, , Z. Rao
The paper reports the cryo-EM structure of 2019-nCoV RdRp complexed with cofactors, revealing key residues and remdesivir binding, aiding antiviral drug design.
bioRxiv · Mar 16, 2020 · PreprintBiochemistry
Z. Jin, X. Du, Y. Xu, Y. Deng, M. Liu, Y. Zhao, B. Zhang, X. Li, L. Zhang, C. Peng, Y. Duan, J. Yu, L. Wang, K. Yang, F. Liu, , H. Yang
The paper identifies a mechanism-based inhibitor of the COVID-19 virus main protease through structure-assisted drug design and high-throughput screening.
bioRxiv · Feb 26, 2020Biochemistry