The importance of the immunodominant CD8+ T cell epitope of Plasmodium berghei circumsporozoite protein in parasite- and vaccine-induced protection
M. P. Gibbins, K. Mueller, J. Liu, M. Glover, E. Putrianti, K. Bauza, A. Reyes-Sandoval, K. Matuschewski, O. Silvie, J. C. Hafalla
This study shows that the SYIPSAEKI epitope of Plasmodium berghei CSP is critical for CD8+ T cell-mediated protection against malaria, but not essential for vaccine-induced immunity in all mouse strains.
bioRxiv · Apr 3, 2020Immunology