Author

O. Silvie

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6 Immunology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Organism:mouse· 8 Research Focus:host-pathogen & immune response· 6 Research Focus:cell type annotation· 4 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 1 Assay:CITE-seq· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

C. Marinach· 5 shared M. Loubens· 4 shared S. Briquet· 4 shared S. Hamada· 4 shared B. Hoareau-Coudert· 3 shared P. Fernandes· 3 shared A. Reyes-Sandoval· 2 shared A.-C. Langlois· 2 shared

Activity by Year

2020-2022 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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5 shared papersMicrobiology

C. Marinach

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

The claudin-like apicomplexan microneme protein is required for gliding motility and infectivity of Plasmodium sporozoites

M. Loubens, C. Marinach, C.-E. Paquereau, S. Hamada, B. Hoareau-Coudert, D. Akbar, J.-F. Franetich, O. Silvie

This paper shows that CLAMP is essential for Plasmodium sporozoite infectivity, gliding motility, and microneme secretion, and is required for invasion of mosquito salivary glands and mammalian hepatocytes.

bioRxiv · Aug 29, 2022 · PreprintMicrobiology

The AMA1-RON complex drives Plasmodium sporozoite invasion in the mosquito and mammalian hosts

P. Fernandes, M. Loubens, R. Le Borgne, C. Marinach, B. Ardin, S. Briquet, L. Vincensini, S. Hamada, B. Hoareau-Coudert, J.-M. Verbavatz, A. Weiner, O. Silvie

This study shows that the AMA1-RON complex is essential for Plasmodium sporozoite invasion of mosquito salivary glands and mammalian hepatocytes, supporting its role in parasite transmission.

bioRxiv · Jan 4, 2022Microbiology

Plasmodium-encoded murine IL-6 impairs liver stage infection and elicits long-lasting sterilizing immunity

S. Belhimeur, S. Briquet, R. Peronet, J. Pham, P.-H. Commere, P. Formaglio, R. Amino, A. Scherf, O. Silvie, S. MECHERI

This study shows that Plasmodium parasites engineered to express murine IL-6 fail to progress to blood stage infection and induce long-lasting CD8+ T cell-mediated immunity.

bioRxiv · Nov 16, 2021Immunology

Plasmodium sporozoites require the protein B9 to invade hepatocytes

P. Fernandes, M. Loubens, C. Marinach, R. Coppee, M. Grand, T.-P. Andre, S. Hamada, A.-C. Langlois, S. Briquet, P. Bun, O. Silvie

This study identifies B9 as a critical protein for Plasmodium sporozoite invasion of hepatocytes, revealing structural and functional similarities to merozoite invasion complexes.

bioRxiv · Oct 25, 2021Microbiology

In-depth proteomic analysis of Plasmodium berghei sporozoites using trapped ion mobility spectrometry with parallel accumulation-serial fragmentation

S. Hamada, C. Pionneau, C. Parizot, O. Silvie, S. Chardonnet, C. Marinach

This study identifies the deep proteome of Plasmodium berghei sporozoites using a highly sensitive mass spectrometer, revealing a core set of proteins across species.

bioRxiv · Nov 26, 2020Microbiology

Low immunogenicity of malaria pre-erythrocytic stages can be overcome by vaccination

K. Mueller, M. P. Gibbins, M. Roberts, A. Reyes-Sandoval, A. Hill, S. Draper, K. Matuschewski, O. Silvie, J. Hafalla

This study shows that poor immunogenicity of EEF antigens does not prevent their susceptibility to CD8+ T cell killing, challenging the assumption that immunogenicity is a key criterion for vaccine development.

bioRxiv · Sep 3, 2020Immunology

The dimerisable Cre recombinase allows conditional genome editing in the mosquito stages of Plasmodium berghei

P. Fernandes, S. Briquet, D. Patarot, M. Loubens, B. Hoareau-Coudert, O. Silvie

This paper implements a dimerisable Cre recombinase system in Plasmodium berghei to enable conditional genome editing in both mammalian and mosquito stages of the parasite.

bioRxiv · Jul 13, 2020Microbiology

The importance of the immunodominant CD8+ T cell epitope of Plasmodium berghei circumsporozoite protein in parasite- and vaccine-induced protection

M. P. Gibbins, K. Mueller, J. Liu, M. Glover, E. Putrianti, K. Bauza, A. Reyes-Sandoval, K. Matuschewski, O. Silvie, J. C. Hafalla

This study shows that the SYIPSAEKI epitope of Plasmodium berghei CSP is critical for CD8+ T cell-mediated protection against malaria, but not essential for vaccine-induced immunity in all mouse strains.

bioRxiv · Apr 3, 2020Immunology

Molecular determinants of SR-B1-dependent Plasmodium sporozoite entry into hepatocytic cells.

A.-C. Langlois, G. Manzoni, L. Vincensini, R. Coppee, C. Marinach, M. Guerin, T. Huby, V. Carriere, F.-L. Cosset, M. Dreux, E. Rubinstein, O. Silvie

This study identifies structural determinants of SR-B1 required for Plasmodium sporozoite entry into hepatocytes using chimeric mouse/human SR-B1 constructs and structure-guided analysis.

bioRxiv · Mar 16, 2020Microbiology