Efficacy of Anti-Staphylococcal Lysin, LSVT-1701, in Combination with Daptomycin in Experimental Left-Sided Infective Endocarditis Due to Methicillin-Resistant Staphylococcus aureus (MRSA)
D. Huang, E. Gaukel, N. Kerzee, K. Borroto-Esoda, S. Lowry, Y. Q. Xiong, W. Abdelhady, A. Bayer
This study evaluates the combined efficacy of the lysin LSVT-1701 and daptomycin in treating MRSA endocarditis in a rabbit model, showing significant reduction in bacterial counts and sterilization of tissues with prolonged lysin treatment.
bioRxiv · Mar 12, 2021Microbiology