A single polymorphic residue in humans underlies species-specific restriction of HSV-1 by the antiviral protein MxB
A. Bayer, S. J. Child, H. S. Malik, A. P. Geballe
The paper identifies a single amino acid variant in MxB that determines HSV-1 restriction in humans, showing that this variant is absent in other primates and has recently become common in humans.
bioRxiv · May 30, 2023Microbiology