S. Chaturvedi

A Dynamical Systems Approach to Optimal Foraging

This paper models optimal foraging using a dynamical system framework, showing adaptive foraging behavior and similarities to neural mechanisms in non-human primates.

Ly6G+Granulocytes-derived IL-17 limits protective host responses and promotes tuberculosis pathogenesis

This study identifies IL-17 and COX2 as negative regulators of protective immunity in tuberculosis, showing that Ly6G+ granulocytes are a major source of IL-17 and their inhibition reduces bacterial burden and pathology.

Antibodies against Elapidae and Viperidae snake venoms: in vivo neutralization and mechanistic insights

This study develops humanized antibody scFvs against Elapidae and Viperidae snake venoms, identifies PLA2 as a key toxin, and shows their in vivo neutralization efficacy.

Host immunosenescence compromises Mycobacterium tuberculosis clearance

This study shows that immunosenescence in older mice impairs Mycobacterium tuberculosis clearance, linked to mitochondrial dysfunction and altered immune cell responses.

A single-administration therapeutic interfering particle reduces SARS-CoV-2 viral shedding and pathogenesis in hamsters

A single dose of therapeutic interfering particles reduces SARS-CoV-2 shedding and transmission in hamsters.

Genomic time-series data show that gene flow maintains high genetic diversity despite substantial genetic drift in a butterfly species

The paper shows that gene flow maintains high genetic diversity in Lycaeides butterflies despite low contemporary effective population sizes and substantial genetic drift.

Transcriptional Feedback Disruption Yields Escape-Resistant Antivirals

This paper develops feedback-circuit disruptors that inhibit viral replication and prevent resistance evolution in herpesviruses.

Pan-resistant Candida auris: New York Sub-cluster Susceptible to Antifungal Combinations

The paper shows that pan-resistant Candida auris strains from a New York outbreak are susceptible to antifungal combinations, despite having mutations in multiple drug targets.

Evaluation of in vitro activity of manogepix against multidrug-resistant and pan-resistant Candida auris from the New York Outbreak

This study evaluates the in vitro activity of manogepix against multidrug-resistant and pan-resistant Candida auris isolates from a New York outbreak, showing it is significantly more active than existing antifungals.

Recent hybrids recapitulate ancient hybrid outcomes

The paper shows that ancestry patterns in ancient hybrid lineages are predictable from contemporary hybrid zones, suggesting similar effects of selection and recombination over time.

In vitro Evaluation of Antifungal Drug Combinations against Multidrug-resistant Candida auris isolates from New York Outbreak

This study evaluates two-drug antifungal combinations against multidrug-resistant Candida auris isolates, finding that flucytosine combinations are most effective in vitro.

In vitro Efficacy of Novel Glucan Synthase Inhibitor, Ibrexafungerp (SCY-078), Against Multidrug- and Pan-resistant Candida auris Isolates from the Outbreak in New York

The paper evaluates the efficacy of the novel glucan synthase inhibitor Ibrexafungerp against multidrug-resistant Candida auris isolates from a New York outbreak, finding it effective with low MIC50 values.

Laboratory Analysis of an Outbreak of Candida auris in New York from 2016 to 2018-Impact and Lessons Learned

This study analyzes a C. auris outbreak in New York, identifying factors contributing to its spread and demonstrating the effectiveness of new detection methods.

A rapid and automated sample-to-result Candida auris real-time PCR assay for high throughput testing of surveillance samples with BD MAX™ open system

This paper develops an automated real-time PCR assay for rapid detection of Candida auris using the BD MAX system, achieving high sensitivity and specificity in clinical samples.

Characterization of novel Chrysosporium morrisgordonii sp. nov., from bat white-nose syndrome (WNS) affected mines, northeastern United States

The paper describes the characterization of a new fungal species, Chrysosporium morrisgordonii, isolated from bat white-nose syndrome affected mines.

Assessment of Environmental and Occupational Exposure while Working with Candida auris a Multidrug Resistant (MDR) Fungus in the Animal Facility.

This study assesses environmental and occupational exposure to Candida auris during animal facility work using murine models and finds dose-dependent shedding and effective mitigation strategies.

The predictability of genomic changes underlying a recent host shift in Melissa blue butterflies

This study examines the predictability of genomic changes during a recent host shift in Melissa blue butterflies, finding partial predictability from lab experiments but limited ability to predict evolutionary direction.