Fundamental transport mechanism of mucin-2 ER-to-Golgi trafficking identifies source of ER stress in inflammatory bowel disease
M. A. J. Morsink, L. S. Koch, S. Hu, R. K. Weersma, H. van Goor, A. R. Bourgonje, K. Broersen
The paper identifies that impaired COPII vesicle enlargement due to reduced TANGO1 expression contributes to ER stress in IBD by affecting mucin-2 secretion.
bioRxiv · May 13, 2024 · PreprintCell Biology