Non-autophagy role of Atg5 and NBR1 in unconventional secretion of IL-12 prevents gut dysbiosis and inflammation
E. F. Castillo, S. D. Merkley, S. M. Goodfellow, Y. Guo, Z. E. R. Wilton, J. R. Byrum, K. C. Schwalm, D. L. Dinwiddie, R. R. Gullapalli, V. P. Deretic, A. Jimenez Hernandez, S. B. Bradfute, J. G. In
This study shows that Atg5 in intestinal myeloid cells limits IL-12 secretion, preventing dysbiosis and inflammation by reducing IFN-gamma production.
bioRxiv · Dec 7, 2020Immunology