Author

S. B. Bradfute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 5 Approach:experimental assay· 4 Organism:human· 2 Assay:metagenomics· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

C. Ye· 4 shared S. M. Goodfellow· 2 shared A. Cox· 1 shared A. Jimenez Hernandez· 1 shared A. Kell· 1 shared A. Kraus· 1 shared C. G. Guo· 1 shared C. Sola-Riera· 1 shared

Activity by Year

2020-2021 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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4 shared papersMicrobiology

C. Ye

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

SARS-COV-2 induced Diarrhea is inflammatory, Ca2+ Dependent and involves activation of calcium activated Cl channels

M. Donowitz, C.-M. Tse, K. Dokladny, M. Rawat, I. Hurwitz, C. Ye, A. Kell, R. Lin, S. Lee, C. G. Guo, S. J. Tsai, A. Cox, S. Gould, J. In, S. B. Bradfute, , O. Kovbasnjuk

This study investigates the pathophysiology of SARS-CoV-2-induced diarrhea, showing it is inflammatory, calcium-dependent, and involves activation of calcium-activated chloride channels.

bioRxiv · Apr 27, 2021 · PreprintPhysiology

Genetic depletion studies define receptor usage by virulent hantaviruses in human endothelial cells

M. E. Dieterle, C. Sola-Riera, R. K. Jangra, C. Ye, S. M. Goodfellow, E. Mittler, E. Kasikci, S. B. Bradfute, J. Klingström, K. Chandran

This study uses CRISPR/Cas9 to knock out potential hantavirus receptors in human endothelial cells, finding that PCDH1 is critical for some hantaviruses while other receptors like integrins and DAF are not essential.

bioRxiv · Dec 30, 2020Microbiology

Non-autophagy role of Atg5 and NBR1 in unconventional secretion of IL-12 prevents gut dysbiosis and inflammation

E. F. Castillo, S. D. Merkley, S. M. Goodfellow, Y. Guo, Z. E. R. Wilton, J. R. Byrum, K. C. Schwalm, D. L. Dinwiddie, R. R. Gullapalli, V. P. Deretic, A. Jimenez Hernandez, S. B. Bradfute, J. G. In

This study shows that Atg5 in intestinal myeloid cells limits IL-12 secretion, preventing dysbiosis and inflammation by reducing IFN-gamma production.

bioRxiv · Dec 7, 2020Immunology

A zebrafish model for COVID-19 recapitulates olfactory and cardiovascular pathophysiologies caused by SARS-CoV-2

A. Kraus, E. Casadei, M. Huertas, C. Ye, S. B. Bradfute, P. Boudinot, J.-P. Levraud, I. Salinas

This study uses zebrafish models to replicate SARS-CoV-2-induced olfactory and cardiovascular effects, showing drug treatment can reverse some symptoms.

bioRxiv · Nov 6, 2020 · PreprintImmunology

Ambroxol and Ciprofloxacin Show Activity Against SARS-CoV2 in Vero E6 Cells at Clinically-Relevant Concentrations

G. S. Timmins, S. B. Bradfute, V. Deretic, S. Kumar, E. C. Clarke, C. Ye

The paper tests drug activity against SARS-CoV-2 in Vero E6 cells and finds ambroxol and ciprofloxacin effective at clinically relevant concentrations.

bioRxiv · Aug 11, 2020 · PreprintMicrobiology