Micrococcin cysteine-to-thiazole conversion through transient interactions between a scaffolding protein and two modification enzymes
D. G. Calvopina-Chavez, D. M. Bursey, Y.-J. Tseng, L. M. Patil, K. D. Bewley, P. R. Bennallack, J. M. McPhie, K. B. Wagstaff, A. Daley, S. M. Miller, J. D. Moody, J. C. Price, J. S. Griffitts
The paper identifies key interactions in the enzymatic complex responsible for converting cysteine to thiazole in micrococcin biosynthesis, revealing a dynamic mechanism involving transient associations between scaffold and modifying enzymes.
bioRxiv · Oct 23, 2023 · PreprintBiochemistry