Author

J. D. Moody

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 3 Research Focus:protein folding & dynamics· 3 Assay:protein structure· 3 Research Focus:protein structure prediction· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1

Frequent Co-Authors

C. Stewart· 3 shared M. J. Pedroza-Romo· 3 shared S. Soleimani· 3 shared T. Doukov· 3 shared D. Bunn· 2 shared P. Gajjar· 2 shared S. Brown· 2 shared T. Smith· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersBiochemistry

C. Stewart

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5 papers

Recent·Most cited

Micrococcin cysteine-to-thiazole conversion through transient interactions between a scaffolding protein and two modification enzymes

D. G. Calvopina-Chavez, D. M. Bursey, Y.-J. Tseng, L. M. Patil, K. D. Bewley, P. R. Bennallack, J. M. McPhie, K. B. Wagstaff, A. Daley, S. M. Miller, J. D. Moody, J. C. Price, J. S. Griffitts

The paper identifies key interactions in the enzymatic complex responsible for converting cysteine to thiazole in micrococcin biosynthesis, revealing a dynamic mechanism involving transient associations between scaffold and modifying enzymes.

bioRxiv · Oct 23, 2023 · PreprintBiochemistry

Fusion crystallization reveals the behavior of both the 1TEL crystallization chaperone and the TNK1 UBA domain

S. Nawarathnage, Y.-J. Tseng, S. Soleimani, T. Smith, M. J. Pedroza-Romo, W. O. Abiodun, C. Egbert, D. Madhysanka, D. Bunn, B. Wood, E. Tsubaki, C. Stewart, S. Brown, T. Doukov, J. Andersen, J. D. Moody

The paper describes the use of TELSAM fusion crystallization to determine the structure of the TNK1 UBA domain and its interaction with polyubiquitin.

bioRxiv · Jun 14, 2023Biochemistry

Decreasing the flexibility of the TELSAM-target protein linker and omitting the cleavable fusion tag improves crystal order and diffraction limits

P. Gajjar, M. J. Pedroza-Romo, C. Litchfield, M. Callahan, N. Redd, S. D. Nawarathnage, S. Soleimani, J. Averett, E. Wilson, A. Lewis, C. Stewart, Y. J. Tseng, T. Doukov, A. Lebedev, J. D. Moody

This study shows that rigidifying the TELSAM-target protein linker and removing the SUMO tag improves crystal diffraction resolution.

bioRxiv · May 12, 2023 · PreprintBiochemistry

TELSAM polymers accelerate crystallization of fused target proteins by stabilizing minimal crystal contacts and in the absence of direct inter-TELSAM contacts

S. D. Sarath Nawarathnage, S. Soleimani, M. H. Mathis, B. D. Bezzant, D. T. Ramirez, P. Gajjar, D. Bunn, C. Stewart, T. Smith, M. J. Pedroza-Romo, S. Brown, T. Doukov, J. D. Moody

This study shows that TELSAM polymers enhance protein crystallization by stabilizing minimal crystal contacts and enabling rapid crystallization without direct inter-TELSAM contacts.

bioRxiv · Jul 23, 2021 · PreprintBiochemistry

Molecular Architecture of the Bardet-Biedl Syndrome 2-7-9 Subcomplex

W. G. Ludlam, T. Aoba, J. Cuellar, M. T. Bueno-Carrasco, A. Makaju, J. D. Moody, S. Franklin, J. M. Valpuesta, B. M. Willardson

The paper determines the structure of a BBSome subcomplex and shows how a mutation disrupts its assembly, linking it to Bardet-Biedl syndrome.

bioRxiv · Jul 11, 2019Biochemistry