Targeted Degradation of Transcription Factors by TRAFTACs: Transcription Factor Targeting Chimeras
K. Samarasinghe, S. Jaime-Figueroa, K. Dai, Z. Hu, C. M. Crews
This study develops TRAFTACs, chimeric oligonucleotides that degrade transcription factors via proteasomal pathway, and demonstrates their effectiveness on NF-κB and brachyury.
bioRxiv · Oct 12, 2020Bioengineering