Author

S. Jaime-Figueroa

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

C. M. Crews· 2 shared J. Hines· 1 shared K. . T. G. Samarasinghe· 1 shared K. Dai· 1 shared K. Samarasinghe· 1 shared L. Vogt· 1 shared N. Rosen· 1 shared S. Alabi· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBioengineering

C. M. Crews

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2 papers

Recent·Most cited

Targeted Degradation of Transcription Factors by TRAFTACs: Transcription Factor Targeting Chimeras

K. Samarasinghe, S. Jaime-Figueroa, K. Dai, Z. Hu, C. M. Crews

This study develops TRAFTACs, chimeric oligonucleotides that degrade transcription factors via proteasomal pathway, and demonstrates their effectiveness on NF-κB and brachyury.

bioRxiv · Oct 12, 2020Bioengineering

Mutant-selective Degradation by BRAF-targeting PROTACs

S. Alabi, S. Jaime-Figueroa, Z. Yao, Y. Gao, J. Hines, K. . T. G. Samarasinghe, L. Vogt, N. Rosen, C. M. Crews

This study develops BRAF-targeting PROTACs that degrade all BRAF mutants at sub-nanomolar concentrations while sparing wild-type RAF family members, showing in vivo efficacy and mechanistic insights.

bioRxiv · Aug 10, 2020Cancer Biology